Description
What is 5-Amino-1MQ?
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule (non-peptide) investigational compound that acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is a metabolic enzyme overexpressed in adipose tissue and linked in preclinical models to reduced cellular NAD+ availability, impaired lipolysis, and obesity. 5-Amino-1MQ is an early-stage research compound; as of current knowledge, no human clinical trials have been published.
Mechanism of Action
- Selective competitive inhibition of NNMT
- Preserves intracellular NAD+ and S-adenosylmethionine pools in adipocytes (preclinical)
- In rodent models, linked to enhanced lipolysis, reduced adipocyte size, and improved metabolic parameters
Compound Properties
- Chemical class: Small-molecule quinolinium derivative (not a peptide)
- Molecular formula: C10H11N2+ (cation); commonly supplied as iodide salt
- Molecular weight: ~159.2 g/mol (cation)
- Form: Lyophilized powder or capsule
- Source reference: PubChem and Kannt et al., 2018
Research-Reference Dosing
All published dosing comes from preclinical animal studies; no human clinical dosing has been established.
- Rodent obesity models: 20 mg/kg/day oral gavage for 11 days in diet-induced obese mice (Neelakantan et al., Biochem Pharmacol 2018)
- No validated human dose exists. Any human-use protocols circulated online are anecdotal and outside regulatory or peer-reviewed research.
Research Findings (Preclinical)
- Reduced white adipose tissue mass and adipocyte size in diet-induced obese mice
- Restored NAD+ and methyl-donor balance in adipose tissue
- Improved markers of metabolic dysfunction in animal models
- No published human efficacy data available
Known Side Effects Reported in Research
Rodent toxicology has reported no overt adverse findings at researched doses. Human safety and adverse-event data are not available.
Storage & Handling
Store at 2–8°C, protected from light and moisture.
Certificate of Analysis
A product-specific Certificate of Analysis (CoA) is available upon request for every lot.
