Pinealon (10mg)

Description

What is Pinealon?

Pinealon (Glu‑Asp‑Arg / EDR) is a synthetic tripeptide from the Khavinson series of “peptide bioregulators” developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is the short synthetic analog of the larger Pineal‑tissue bioregulator, claimed in the Russian literature to have neuroprotective, antioxidant, and cognition‑supporting effects in aged animals and in stress models.

Mechanism of Action

• Proposed epigenetic regulation: the Khavinson model suggests tri/tetrapeptide bioregulators enter cells and bind to specific promoter regions of DNA to modulate gene expression (mechanism debated outside Khavinson literature)
• Attenuates lipid peroxidation and ROS in neuronal culture and rodent CNS models
• Reduces apoptosis of hippocampal neurons after hypoxia in rats
• Claimed circadian and melatonin‑pathway modulation in aged animals

Compound Properties

• Sequence: Glu‑Asp‑Arg (EDR)
• Molecular formula: C₁₅H₂₆N₆O₈
• Molecular weight: ~418.4 g/mol
• Form: Lyophilized powder
• Unit size: 10 mg / vial
• Source: Solid‑phase peptide synthesis; ≥98% purity by HPLC

Research‑Reference Dosing

Published research‑reference ranges:

• Khavinson et al., Bulletin of Experimental Biology and Medicine: preclinical characterization of EDR tripeptide.
• Arutjunyan et al., Advances in Gerontology: antioxidant and behavioral studies in rodents.
• Chalisova et al.: cell‑culture cytoprotection data.
• Peer‑reviewed Western‑journal data and human clinical trials are limited.

Research Findings

• Reduced oxidative‑stress markers and improved learning/memory in aged and hypoxic rodent models
• Cytoprotection in neuronal culture
• Evidence base is Russian‑dominated; Western replication limited

Known Side Effects Reported in Research/Trials

• Generally well tolerated in published cohorts
• Rare injection‑site reactions
• Long‑term human safety data is limited

Storage & Handling

• Lyophilized (unreconstituted) vials: store at −20°C long‑term; short‑term 2–8°C acceptable.
• After reconstitution with bacteriostatic or sterile water: store at 2–8°C; use within 14–28 days per standard peptide stability guidance.
• Protect from light, heat, and repeated freeze‑thaw cycles. Handle in a sterile laboratory environment.

Certificate of Analysis

A Certificate of Analysis (COA) confirming identity and purity by HPLC / MS is available upon request. Contact Lonestar Peptides for lot‑specific documentation.

Summaries reference peer‑reviewed preclinical and clinical literature available as of early 2025. Newer findings may not be reflected. Researchers should consult current literature and conduct their own due diligence. Lonestar Peptides makes no claim of therapeutic benefit.